Abstract
As the core coordinating body for global health governance, the World Health Organization (WHO) now faces a structural turning point following the formal termination of cooperation by the United States. From a professional perspective, this paper analyzes the profound impact of the U.S. withdrawal across three core pillars: global pandemic surveillance systems, immunization programs and disease eradication initiatives, and the prevention and control of non-communicable diseases (NCDs) and antimicrobial resistance (AMR). It identifies governance risks such as surveillance fragmentation, standard divergence, and the loss of professional resources. Furthermore, aligned with global health development needs, this paper proposes new collaborative pathways—strengthening regional governance, deepening scientific research collaboration, optimizing public-private partnerships, and advancing digital infrastructure—to provide a framework for constructing a more resilient global health governance system.
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